Application of Functional Renal MRI to improve assessment of chronic kidney disease (AFiRM)

Magnetic resonance imaging (MRI) allows us to see inside the human body in amazing detail. However, when it comes to the kidneys, MRI is not routinely used in clinical practice. 

MRI can measure different processes that can cause kidney disease, including altered tissue microstructure (inflammation/fibrosis), oxygenation and perfusion.

Research is needed to work out how these MRI techniques can help people suffering from kidney disease. To address this, the AFiRM study has been designed and developed by a team of researchers from across the UK.

The AFiRM study will use MRI to determine the severity and nature of kidney disease in 450 people, and then use these to track changes over time. By doing so, we hope to show how kidney MRI can improve the way that patients with kidney disease are assessed, which ultimately may allow better, more individualised treatments.

About the AFiRM Study >

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Chief Investigator
Nicholas Selby

Susan Francis
Maarten Taal
Steven Sourbron
Iosif Mendichovszky
Phil Kalra
Mark Gilthorpe

Derby Clinical Trials Support Unit (Derby CTSU)
Trial Managers
Data Managers

Additional Info

University Hospitals of Derby & Burton NHS Foundation Trust
Clinical Trials Unit:
Derby Clinical Trials Support Unit are providing trial management and data management for the study.
National Institute for Health Research Efficacy and Mechanism Evaluation (EME) Identifier:  NCT04238299
Collaborating with:
UKRIN MAPS - The University of Nottingham