The Renal Risk in Derby (RRID) Study is a prospective cohort study of people with CKD stage 3 in primary care. Recruitment began in June 2008 and completed in April 2010. Year-5 follow-up visits were completed in April 2015. Year-10 follow-up is currently underway but is limited to data collection. No further participant visits are planned.
Background and Rationale for the RRID study
- Chronic kidney disease affects 10-20% of adults in most countries and is associated with multiple adverse outcomes including increased risk of death, progression to end-stage kidney disease (requiring dialysis or kidney transplantation) and increased risk of diseases of the heart and arteries.
- The risk of these adverse outcomes varies considerably and previous studies indicate that most people with chronic kidney disease are at low risk.
- Many previous studies have been conducted in large teaching hospitals and have understandably emphasized the risk of end-stage kidney disease but the results may not be applicable to the majority with chronic kidney disease because most have mild disease, are cared for by family doctors and are never referred to a kidney specialist.
- We started the RRID study to better understand the risks associated with chronic kidney disease in people cared for by family doctors in order to provide a perspective that is applicable to the majority of people affected.
- We plan to investigate the role of a range of common clinical variables and novel factors (including skin autoflourescence, pulse wave velocity and cystatin C) in determining risk for individuals with CKD stage 3 in primary care.